In leukemia, the immature or abnormal cells that undergo uncontrolled expansion, resulting in an overproduction of these white blood cells and frequently, the inability to produce enough red blood cells and platelets. In the case of acute leukemias, the normal differentiation pathway is blocked at a stage where the cells are still proliferating but do not move into terminal differentiation. According to the 2018 GLOBOCAN survey, cases of leukemia are on the rise worldwide: 437,033 new cases of leukemia were registered with a global incidence rate of 5.2 and a mortality rate of 3.5 (ASR per 100,000).1 Based on the progenitor cell in the bone marrow, leukemia can be lymphocytic or myelocytic. Lymphocytic (lymphoblastic) leukemia arises from T or B lymphocytic progenitors whereas non-lymphocytic or myeloid leukemia arises from progenitors of erythrocytes, granulocytes, monocytes or platelets.1
BD Biosciences clinical flow cytometry solutions, including instrumentation, software and reagents, offer the building blocks for laboratory-developed tests used in the identification of markers associated with leukemias / lymphomas.
These solutions are not FDA cleared or approved for the diagnosis of leukemias. Analyte Specific Reagent.
Analytical and performance characteristics are not established.