Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient’s blood and immune cell production capacity. Every year, >30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT).1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma.
The BD®™ Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/μL) as well as the percentage of the total viable leukocyte count that is CD34+ (%CD34). The following specimens can be analyzed with this kit: normal and mobilized peripheral blood, fresh and thawed leukopheresis products, fresh and thawed bone marrow, and fresh and thawed cord blood. The kit is intended for in vitro diagnostic (IVD) use on either a BD FACSCalibur™ Flow Cytometer using BD CellQuest™ or BD CellQuest™ Pro Software or a BD FACSCanto™ II Flow Cytometer using BD FACSCanto™ Clinical Software.
BD FACSCanto™ II and BD FACSCalibur™BD flow cytometers are Class 1 Laser Products.
BD™ Stem Cell Enumeration (SCE) Kit, BD™ Stem Cell Control, BD FACSCanto™ II, BD FACSCalibur™ and BD FACSCanto™ Clinical Software are CE marked in compliance with the European In Vitro Diagnostic Medical Device Directive 98/79/EC.