BD Pharmingen™ Purified Mouse Anti-Human MUC2
Clone CCP58
Preparation And Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Companion Products
Reacts with the core peptide of the MUC2 protein, a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kD) and an amino acid composition rich in serine, threonin, proline and glycine. The core protein contains a domain of 23 amino-acid tandem repeats which function as multiple epitopes for the monoclonal antibody. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This antibody has been shown to be relatively tissue specific, being associated predominantly with intestinal tissue and is highly reactive with colon and gastric tumors. The antibody is suitable for staining formalin-fixed, paraffin-embedded tissue sections following citrate pretreatment.
Development References (2)
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Devine PL, Birrell GW, Whitehead RH, Harada H, Xing PX, McKenzie IF. Expression of MUC1 and MUC2 mucins by human tumor cell lines. Tumour Biol. 1992; 13(5):268-277. (Biology: Immunohistochemistry-formalin (antigen retrieval required), Immunohistochemistry-frozen). View Reference
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Xing PX, Prenzoska J, Layton GT, Devine PL, McKenzie IF. Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. J Natl Cancer Inst. 1992; 84(9):699-703. (Biology: Immunohistochemistry-formalin (antigen retrieval required), Immunohistochemistry-frozen). View Reference
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Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
