Quality and Reproducibility

BD Biosciences identifies key targets of interest in scientific research and develops its own specific antibodies or collaborates with top research scientists around the world to license their antibodies. We then transform these antibodies into flow cytometry reagents by conjugating them to a broad portfolio of high-performing dyes, including our vastly popular portfolio of BD Horizon Brilliant™ Dyes.

A world-class team of research scientists helps ensure that these reagents work reliably and consistently for flow cytometry applications.

The specificity is confirmed using multiple methodologies that may include a combination of flow cytometry, immunofluorescence, immunohistochemistry or western blot to test staining on a combination of primary cells, cell lines or transfectant models.

All flow cytometry reagents are titrated on the relevant positive or negative cells. To save time and cell samples for researchers, test size reagents are bottled at an optimal concentration with the best signal-to-noise ratio on relevant models during the product development. To ensure consistent performance from lot-to-lot, each reagent is bottled to match the previous lot MFI. You can look up the Certificate of Analysis and the concentration of test-size human reagents from specific lots via the Concentration Lookup page or BD Regulatory Documents.

Technical data sheets provide data generated on the relevant primary model at this optimal concentration based on a titration curve. QC data on any lot of reagent can be requested through ResearchApplications@bd.com.

Our dedication to rigorous testing and high-quality control standards means that you can use our reagents in your research with the utmost confidence. All BD reagent facilities, including our California Design Center at San Diego, our manufacturing facilities in Tatabanya (Hungary) and San Diego (USA), and our California instrument facility (Manufacturing and Design Centers) at San Jose, are approved and registered according to the internationally defined ISO 9001 standard.

Once our research and development (R&D) team completes evaluation of a new product, the developed process is transferred to our manufacturing teams, including Quality Control..

Our manufacturing process adheres to standard operating procedures (SOPs) and guidelines, which are based on ISO requirements and are strictly followed, helping ensure that reagents provide consistent results to help give you assurance of experimental success and confidence in your research.
 

Quality control testing of newly manufactured lots is performed side-by-side with a previously accepted lot as a control, helping to assure that performance of the new lot is both reliable and consistent.

We understand the criticality of lot-to-lot consistency in helping you obtain experimental success and confidence in your research. We strive to ensure different production batches are consistent regardless of type of antigen or fluorochrome through exhaustive testing and strict adherence to quality control standards. Testing with prior batches as reference helps you obtain consistent results with the new batch relative to the previous batches.

BD research cytometers represent quality, relentless innovation and tireless dedication to service. Our platforms continue to keep pace with the accelerating speed of discovery through ongoing innovation. BD FACSDiva™, BD FACSuite™ and BD FACSChorus™ Software provide one of the most complete and robust feature sets available for flow cytometry.

BD® CS&T Research Beads are specifically designed to take advantage of the automated cytometer setup and performance tracking features of BD FACSDiva™, BD FACSuite™ and BD FACSChorus™ Software to simplify setup with a single-vial reagent solution.